08-P001 Interkinetic nuclear migration in the zebrafish retina: Actomyosin contraction is the prime mover

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08-P001 Interkinetic nuclear migration in the zebrafish retina: Actomyosin contraction is the prime mover

As the neurogenerative epithelium of the vertebrate central nervous system expands during embryonic development, nuclei of neural progenitors undergo a process called interkinetic nuclear migration (IKNM). The nuclear movements of IKNM are generally believed to involve gradual migrations from apical to basal and back during the G1 and G2 phases of the cell cycle, respectively. Yet the kinetics ...

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Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina

Progenitor cell nuclei in the rapidly expanding epithelium of the embryonic vertebrate central nervous system undergo a process called interkinetic nuclear migration (IKNM). Movements of IKNM are generally believed to involve smooth migration of nuclei from apical to basal and back during the G1 and G2 phases of the cell cycle, respectively. Yet, this has not been formally demonstrated, nor hav...

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Interkinetic nuclear migration: cell cycle on the move.

Interkinetic nuclear migration (INM) is a common feature of developing neuroepithelia, consisting of the periodic movement of the cell nucleus in phase with cell-cycle progression. In this issue of The EMBO Journal, Kosodo et al provide a first molecular mechanism to couple nuclear migration and cell cycle: the microtubule-associated protein Tpx2 redistributes from the nucleus to the apical pro...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2009

ISSN: 0925-4773

DOI: 10.1016/j.mod.2009.06.308